癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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CHRNA4 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P43681 |
| Other Accession | NM_000744, NP_000735 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 69957 Da |
| Gene ID | 1137 |
|---|---|
| Alias Symbol | BFNC, EBN, EBN1, NACRA4, NACHR, NACHRA4 |
| Other Names | Neuronal acetylcholine receptor subunit alpha-4, CHRNA4, NACRA4 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CHRNA4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CHRNA4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHRNA4 (HGNC:1958) |
|---|---|
| Synonyms | NACRA4 |
| Function | Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system (PubMed:16835356, PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (PubMed:27698419, PubMed:29720657, PubMed:38454578). Involved in the modulation of calcium-dependent signaling pathways, influences the release of neurotransmitters, including dopamine, glutamate and GABA (By similarity). |
| Cellular Location | Synaptic cell membrane {ECO:0000250|UniProtKB:O70174}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:O70174}; Multi-pass membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Fedi,M., (2008) J. Clin. Endocrinol. Metab. 93 (2), 634-637 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Ishizuka, T., Ozawa, A., Goshima, H. & Watanabe, Y. Involvement of nicotinic acetylcholine receptor in the proliferation of mouse induced pluripotent stem cells. Life Sci. 90, 637-48 (2012). WB, Mouse, Guinea pig, Human, Rat, Dog, Zebrafish, Bovine, H, Rabbit22483693
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