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TPCN1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9ULQ1 |
| Other Accession | NM_017901, NP_060371 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rabbit, Pig, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 94147 Da |
| Gene ID | 53373 |
|---|---|
| Alias Symbol | FLJ20612, KIAA1169, TPC1 |
| Other Names | Two pore calcium channel protein 1, Voltage-dependent calcium channel protein TPC1, TPCN1, KIAA1169, TPC1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TPCN1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TPCN1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TPCN1 (HGNC:18182) |
|---|---|
| Function | Intracellular channel initially characterized as a non- selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly- selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable) (PubMed:23394946). Ion selectivity is not fixed but rather agonist- dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable) (PubMed:23394946). |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane {ECO:0000250|UniProtKB:Q9EQJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQJ0}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9EQJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQJ0} |
| Tissue Location | Highest expression found in the heart and kidney, and lowest expression found in the spleen |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Clapham,D.E. (2005) Pharmacol. Rev. 57 (4), 451-454Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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