癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GABRE antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P78334 |
| Other Accession | NM_021984, NP_068819 |
| Reactivity | Human, Mouse, Rat, Rabbit |
| Predicted | Human, Mouse, Rat, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57972 Da |
| Gene ID | 2564 |
|---|---|
| Other Names | Gamma-aminobutyric acid receptor subunit epsilon, GABA(A) receptor subunit epsilon, GABRE |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-GABRE antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GABRE antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GABRE (HGNC:4085) |
|---|---|
| Function | Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:9882711). GABA- gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (PubMed:16412217, PubMed:9882711). GABARs containing epsilon subunit may regulate cardiac function (Probable). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in many tissues (PubMed:9339354). Highest levels of expression in adult heart and placenta (PubMed:9084408, PubMed:9339354, PubMed:9882711). |
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Sinkkonen,S.T., et al., (2000) J. Neurosci. 20 (10), 3588-3595Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Hengen, K. B., Gomez, T. M., Stang, K. M., Johnson, S. M. & Behan, M. Changes in ventral respiratory column GABAaR ε- and δ-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R272-83 (2011). WB, IHC, IP, Human, Rat, Rabbit, Mouse, Guinea pig21084677Hengen, K. B. et al. Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. PLoS One 7, e30608 (2012). WB, IHC, IP, Human, Rat, Rabbit, Mouse, Guinea pig22303446Fatemi, S. H., Folsom, T. D., Rooney, R. J. & Thuras, P. D. Expression of GABAA -alpha2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder. Transl. Psychiatry 3, e303 (2013). WB, IHC, IP, Human, Rat, Rabbit, Mouse, Guinea pig24022508
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