癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TDRD9 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8NDG6 |
| Other Accession | NM_153046, NP_694591 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine, Yeast |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 155683 Da |
| Gene ID | 122402 |
|---|---|
| Alias Symbol | C14orf75, HIG-1, NET54 |
| Other Names | Putative ATP-dependent RNA helicase TDRD9, 3.6.4.13, Tudor domain-containing protein 9, TDRD9, C14orf75 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TDRD9 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TDRD9 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TDRD9 (HGNC:20122) |
|---|---|
| Function | ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q14BI7}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP- bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies {ECO:0000250|UniProtKB:Q14BI7} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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