癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTRF antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | O54724 |
| Other Accession | NM_008986, NP_033012 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43954 Da |
| Gene ID | 19285 |
|---|---|
| Alias Symbol | Cavin, Cav-p60, AW546441, 2310075E07Rik |
| Other Names | Polymerase I and transcript release factor, Cav-p60, Cavin-1, Ptrf {ECO:0000312|MGI:MGI:1277968} |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-PTRF antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PTRF antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Cavin1 |
|---|---|
| Synonyms | Ptrf {ECO:0000312|MGI:MGI:1277968} |
| Function | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:18840361, PubMed:30188967). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242). Essential for normal oligomerization of CAV1 (PubMed:23652019). Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195). Dissociates transcription complexes paused by DNA- bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:10589839, PubMed:11139612, PubMed:9582279). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (PubMed:30188967). |
| Cellular Location | Membrane, caveola. Cell membrane. Microsome {ECO:0000250|UniProtKB:Q6NZI2}. Endoplasmic reticulum. Cytoplasm, cytosol Mitochondrion {ECO:0000250|UniProtKB:Q6NZI2}. Nucleus Note=Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin- dependent manner (PubMed:19546242). {ECO:0000250|UniProtKB:Q6NZI2, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:19546242} |
| Tissue Location | Expressed in the heart, stomach, adipose tissue and lung (at protein level). Expressed in testis, kidney, muscle, liver, spleen and brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Miyoshi,K., et al., (2001) Genomics 71 (2), 150-155Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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