癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Tsc22d4 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9EQN3 |
| Other Accession | NM_023910, NP_076399 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39979 Da |
| Gene ID | 78829 |
|---|---|
| Alias Symbol | 0610009M14Rik, 1700023B23Rik, Thg-1pit, Tilz2, AI415410 |
| Other Names | TSC22 domain family protein 4, TSC22-related-inducible leucine zipper protein 2, Thg-1pit, Tsc22d4, Thg1pit, Tilz2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-Tsc22d4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Tsc22d4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Tsc22d4 {ECO:0000250|UniProtKB:Q9Y3Q8} |
|---|---|
| Function | Binds DNA and acts as a transcriptional repressor (PubMed:27827363). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (PubMed:27827363). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low- density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (PubMed:20878296). |
| Cellular Location | Nucleus. Cytoplasm. Cell projection, dendrite. Synapse Note=Localizes away from the nucleus to neurite processes and synaptic termini as cerebellar granular neurons differentiate (PubMed:20878296) Accumulates in the cytoplasm of differentiated Purkinje cells (PubMed:20878296). Localized to both the cytoplasm and nucleus in immature cerebellar granular neurons and atrophic Purkinje cells (PubMed:20878296). |
| Tissue Location | Expressed in the liver (at protein level) (PubMed:23307490, PubMed:27827363). Expressed in Purkinje cells and proliferating cerebellar granular neurons (at protein level) (PubMed:20878296). Expressed in the cortex, medulla and papilla of the kidney. |
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Canterini,S., (2005) Dev. Dyn. 234 (3), 689-697 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Canterini, S., Carletti, V., Nusca, S., Mangia, F. & Fiorenza, M. T. Multiple TSC22D4 iso-/phospho-glycoforms display idiosyncratic subcellular localizations and interacting protein partners. FEBS J. 280, 1320-9 (2013). WB, IP, Rat, Mouse, Pig, Guinea pig, Human, H, Rabbit, Bovine, Dog23305244
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