癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PARN antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8VDG3 |
| Other Accession | NM_028761, NP_083037 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 71559 Da |
| Gene ID | 74108 |
|---|---|
| Alias Symbol | DAN, 1200003I18Rik |
| Other Names | Poly(A)-specific ribonuclease PARN, 3.1.13.4, Polyadenylate-specific ribonuclease, Parn |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-PARN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PARN antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Parn |
|---|---|
| Function | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU- rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to leading to microRNAs degradation or snoRNA increased stability (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:O95453}. Cytoplasm {ECO:0000250|UniProtKB:O95453}. Nucleus, nucleolus {ECO:0000250|UniProtKB:O95453}. Note=Some nuclear fraction is nucleolar. {ECO:0000250|UniProtKB:O95453} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Katayama,S., et al., (2005) Science 309 (5740), 1564-1566Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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