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L3mbtl antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | A2A5N8 |
| Other Accession | XM_485097, XP_485097 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Horse |
| Predicted | Rabbit, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 91781 Da |
| Gene ID | 241764 |
|---|---|
| Alias Symbol | C630004G01, KIAA0681, L3MBTL1, mKIAA0681, L3mbtl |
| Other Names | Lethal(3)malignant brain tumor-like protein 1, H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog, L3mbtl1, Kiaa0681, L3mbt, L3mbtl |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-L3mbtl antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | L3mbtl antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | L3mbtl1 |
|---|---|
| Synonyms | Kiaa0681, L3mbt, L3mbtl |
| Function | Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53- target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys- 860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity). |
| Cellular Location | Nucleus. Note=Excluded from the nucleolus. Does not colocalize with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex (By similarity). |
| Tissue Location | Highly expressed in brain, testis, eyes, and ES cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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