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Gria1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P23818 |
| Other Accession | NM_001113325, NP_001106796 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rabbit, Zebrafish, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 101569 Da |
| Gene ID | 14799 |
|---|---|
| Alias Symbol | 2900051M01Rik, AI853806, Glr-1, Glr1, GluR-A, GluRA, Glur-1, Glur1, HIPA1, GluA1, gluR-K1 |
| Other Names | Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1, Gria1, Glur1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Gria1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Gria1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Gria1 {ECO:0000312|MGI:MGI:95808} |
|---|---|
| Function | Ionotropic glutamate receptor that functions as a ligand- gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1699805). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Postsynaptic cell membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Cell projection, dendrite Cell projection, dendritic spine. Early endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Recycling endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Presynapse. Synapse Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (PubMed:18341993). Localized to cone photoreceptor pedicles (PubMed:28334377). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:18341993, ECO:0000269|PubMed:28334377} |
| Tissue Location | Expressed in the outer plexiform layer of the retina of the eye (at protein level) (PubMed:28334377). Expressed in the forebrain and hippocampus (at protein level) (PubMed:31651360) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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