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SCN3B antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9NY72 |
| Other Accession | NM_018400, NP_060870 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24702 Da |
| Gene ID | 55800 |
|---|---|
| Alias Symbol | HSA243396, SCNB3 |
| Other Names | Sodium channel subunit beta-3, SCN3B, KIAA1158 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SCN3B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SCN3B antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SCN3B (HGNC:20665) |
|---|---|
| Synonyms | KIAA1158 |
| Function | Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:20558140, PubMed:21051419). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5 (PubMed:20558140, PubMed:21051419, PubMed:24567321, PubMed:31950564). Could also regulate the atypical sodium channel SCN7A/Nav2.1 (PubMed:35301303). Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (PubMed:14975698). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in the atrium. |
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Kimura,K., et al., (2006) Genome Res. 16 (1), 55-65Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Hu, D. et al. A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype. Circ. Cardiovasc. Genet. 2, 270-8 (2009). WB, Mouse, Human, H, Rabbit, Bovine, Rat, Dog, Guinea pig20031595Ho, C., Zhao, J., Malinowski, S., Chahine, M. & O’Leary, M. E. Differential expression of sodium channel β subunits in dorsal root ganglion sensory neurons. J. Biol. Chem. 287, 15044-53 (2012). WB, Mouse, Human, H, Rabbit, Bovine, Rat, Dog, Guinea pig22408255
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