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>   首页   >   产品   >   一抗   >   精选抗体   >   斑马鱼抗体   >   Ppargc1a antibody - C-terminal region   

Ppargc1a antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • 1 - Ppargc1a antibody - C-terminal region AI11479

    WB Suggested Anti-Ppargc1a Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: Mouse Brain
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O70343
Other Accession NM_008904, NP_032930
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Goat, Dog, Horse, Bovine
Predicted Human, Mouse, Rabbit, Zebrafish, Pig, Chicken, Goat, Dog, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 90588 Da
Additional Information
Gene ID 19017
Alias Symbol A830037N07Rik, PGC-1, PGC-1v, Pgc-1alpha, Pgc1, Pgco1, Ppargc1, Gm11133, ENSMUSG00000079510
Other Names Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, Ppargc1a, Pgc1, Pgc1a, Ppargc1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Ppargc1a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPpargc1a antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ppargc1a
Synonyms Pgc1, Pgc1a, Ppargc1
Function Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:12754525). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (By similarity). Also involved in the integration of the circadian rhythms and energy metabolism (PubMed:17476214). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (PubMed:17476214).
Cellular Location Nucleus. Nucleus, PML body
Tissue Location White quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level) Skeletal muscle, brown adipose tissue, heart, kidney and brain
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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