癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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Kbtbd5 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9D783 |
| Other Accession | NM_028202, NP_082478 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine |
| Predicted | Rabbit, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 69589 Da |
| Gene ID | 72330 |
|---|---|
| Alias Symbol | 2310024D23Rik, Kbtbd5 |
| Other Names | Kelch-like protein 40, Kelch repeat and BTB domain-containing protein 5, Klhl40, Kbtbd5 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Kbtbd5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Kbtbd5 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Klhl40 {ECO:0000312|MGI:MGI:1919580} |
|---|---|
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:25940086). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (PubMed:25940086). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (PubMed:24960163). |
| Cellular Location | Cytoplasm. Cytoplasm, myofibril, sarcomere, A band Cytoplasm, myofibril, sarcomere, I band |
| Tissue Location | Specifically expressed in skeletal muscles in embryonic, neonatal and adults (PubMed:24960163, PubMed:25940086) Expressed in various types of muscles, including extensor digitorum longus, gastrocnemius, soleus, diaphragm, masseter and heart (at protein level). Not detected in brain, liver and lung (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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