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RG9MTD1 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q7L0Y3 |
| Other Accession | NM_017819, NP_060289 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Horse, Bovine |
| Predicted | Human, Rabbit, Zebrafish |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47347 Da |
| Gene ID | 54931 |
|---|---|
| Alias Symbol | FLJ20432, MRPP1, RG9MTD1 |
| Other Names | Mitochondrial ribonuclease P protein 1, Mitochondrial RNase P protein 1, 2.1.1.-, HBV pre-S2 trans-regulated protein 2, RNA (guanine-9-)-methyltransferase domain-containing protein 1, Renal carcinoma antigen NY-REN-49, tRNA methyltransferase 10 homolog C, TRMT10C, MRPP1, RG9MTD1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RG9MTD1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RG9MTD1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRMT10C (HGNC:26022) |
|---|---|
| Function | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. |
| Cellular Location | Mitochondrion matrix, mitochondrion nucleoid |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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