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SUPT4H1 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P63272 |
| Other Accession | NM_003168, NP_003159 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Chicken, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13193 Da |
| Gene ID | 6827 |
|---|---|
| Alias Symbol | SPT4H, SUPT4H, SPT4 |
| Other Names | Transcription elongation factor SPT4, hSPT4, DRB sensitivity-inducing factor 14 kDa subunit, DSIF p14, DRB sensitivity-inducing factor small subunit, DSIF small subunit, SUPT4H1, SPT4H, SUPT4H |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SUPT4H1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SUPT4H1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SUPT4H1 |
|---|---|
| Synonyms | SPT4H, SUPT4H |
| Function | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10454543, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:15136722). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10199401, PubMed:10912001, PubMed:11112772). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10199401, PubMed:10912001, PubMed:11112772). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:10199401, PubMed:10912001, PubMed:11112772). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:11112772). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772). |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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