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VPS41 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P49754 |
| Other Accession | NM_080631, NP_542198 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 98566 Da |
| Gene ID | 27072 |
|---|---|
| Alias Symbol | HVPS41, HVSP41, hVps41p |
| Other Names | Vacuolar protein sorting-associated protein 41 homolog, S53, VPS41 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-VPS41 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | VPS41 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VPS41 |
|---|---|
| Function | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5- to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085, PubMed:33851776). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:23167963, PubMed:25445562, PubMed:25908847, PubMed:9159129). Required for fusion of autophagosomes with lysosomes (PubMed:25783203, PubMed:37821429). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:21802320, PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660). |
| Cellular Location | Endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Golgi apparatus, trans- Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasm, cytosol |
| Tissue Location | Expressed in cerebral cortex and cerebellum. Highly expressed in Purkinje cells. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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