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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRAF7 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q6Q0C0 |
| Other Accession | NM_032271, NP_115647 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Chicken, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74609 Da |
| Gene ID | 84231 |
|---|---|
| Alias Symbol | DKFZp586I021, MGC7807, RFWD1, RNF119 |
| Other Names | E3 ubiquitin-protein ligase TRAF7, 6.3.2.-, RING finger and WD repeat-containing protein 1, RING finger protein 119, TNF receptor-associated factor 7, TRAF7, RFWD1, RNF119 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TRAF7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TRAF7 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRAF7 |
|---|---|
| Synonyms | RFWD1, RNF119 |
| Function | E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3- mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). |
| Cellular Location | Cytoplasmic vesicle. Cytoplasm. Nucleus Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm |
| Tissue Location | Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Xu,L.G.,(2004)J.Biol.Chem.279(17),17278-17282ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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