癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Slc22a3 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9WTW5 |
| Other Accession | NM_011395, NP_035525 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Bovine |
| Predicted | Human, Mouse, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61053 Da |
| Gene ID | 20519 |
|---|---|
| Alias Symbol | EMT, Oct3, Orct3, Slca22a3 |
| Other Names | Solute carrier family 22 member 3, Organic cation transporter 3, Slc22a3, Oct3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Slc22a3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Slc22a3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Slc22a3 {ECO:0000312|MGI:MGI:1333817} |
|---|---|
| Function | Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10966924, PubMed:18513366). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)- independent, bidirectional uniporter (By similarity). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, homovanillic acid, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:18513366, PubMed:19416912). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (By similarity). Also transports guanidine (PubMed:10966924). Mediates the transport of choline (By similarity). May mediate intracellular transport of organic cations due to its localization on endomembranes, thereby contributing to amine metabolism and intracellular signaling (PubMed:27659446). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O75751}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:O75751}; Multi-pass membrane protein. Mitochondrion membrane Endomembrane system. Nucleus membrane. Nucleus outer membrane {ECO:0000250|UniProtKB:O88446}. Note=Located to neuronal and glial endomembranes, including mitochondrial and nuclear membranes |
| Tissue Location | Highly expressed in placenta (PubMed:10966924, PubMed:9933568). Highly expressed in kidney cortex (PubMed:10966924) In kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule (PubMed:10966924). Expressed in brain, particularly in dopaminergic neurons of the substantia nigra compacta, non-aminergic neurons of the ventral tegmental area, substantia nigra reticulata, locus coeruleus, hippocampus and cortex (PubMed:18513366). In brain, also detected in astrocytes in the substantia nigra reticulata, several hypothalamic nuclei and nigrostriatal region (PubMed:18513366, PubMed:19416912). Expressed in neurons and glial cells of amygdala (PubMed:27659446) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
