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CISD2 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8N5K1 |
| Other Accession | NM_001008388, NP_001008389 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15278 Da |
| Gene ID | 493856 |
|---|---|
| Alias Symbol | ERIS, Miner1, WFS2, ZCD2, NAF-1 |
| Other Names | CDGSH iron-sulfur domain-containing protein 2, Endoplasmic reticulum intermembrane small protein, MitoNEET-related 1 protein, Miner1, Nutrient-deprivation autophagy factor-1, NAF-1, CISD2, CDGSH2, ERIS, ZCD2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CISD2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CISD2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CISD2 |
|---|---|
| Synonyms | CDGSH2, ERIS, ZCD2 |
| Function | Regulator of autophagy that contributes to antagonize BECN1- mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane |
| Tissue Location | Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Amr,S.,(2007)Am.J.Hum.Genet.81(4),673-683ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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