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NCAPD2 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • 1 - NCAPD2 antibody - C-terminal region AI12663

    WB Suggested Anti-NCAPD2 Antibody Titration: 0.2-1 μg/ml
    Positive Control: Jurkat cell lysate
  • 1 - NCAPD2 antibody - C-terminal region AI12663

    Host:Rabbit
    Target Name:NCAPD2
    Sample Tissue:Hela
    Antibody Dilution: 1.0μg/mlNCAPD2 is supported by BioGPS gene expression data to be expressed in HeLa
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q15021
Other Accession NM_014865, NP_055680
Reactivity Human, Rabbit, Pig, Dog, Horse
Predicted Human, Rabbit, Pig, Dog, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 157182 Da
Additional Information
Gene ID 9918
Alias Symbol CAP-D2, CNAP1, KIAA0159, hCAP-D2
Other Names Condensin complex subunit 1, Chromosome condensation-related SMC-associated protein 1, Chromosome-associated protein D2, hCAP-D2, Non-SMC condensin I complex subunit D2, XCAP-D2 homolog, NCAPD2, CAPD2, CNAP1, KIAA0159
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-NCAPD2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsNCAPD2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCAPD2 {ECO:0000303|PubMed:27737959, ECO:0000312|HGNC:HGNC:24305}
Function Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).
Cellular Location Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

Lee,J.H.,(er)Neurogenetics(2008)InpressReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.

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