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UGT1A4 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P22310 |
| Other Accession | NM_007120, NP_009051 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60025 Da |
| Gene ID | 54657 |
|---|---|
| Alias Symbol | HUG-BR2, UDPGT, UGT1D, UGT-1D, UGT1.4, UGT1-04, UDPGT 1-4 |
| Other Names | UDP-glucuronosyltransferase 1-4, UDPGT 1-4, UGT1*4, UGT1-04, UGT1.4, 2.4.1.17, Bilirubin-specific UDPGT isozyme 2, hUG-BR2, UDP-glucuronosyltransferase 1-D, UGT-1D, UGT1D, UDP-glucuronosyltransferase 1A4, UGT1A4, GNT1, UGT1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-UGT1A4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | UGT1A4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | UGT1A4 (HGNC:12536) |
|---|---|
| Synonyms | GNT1, UGT1 |
| Function | [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623, PubMed:15231852). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842, PubMed:20133892). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE and PGB1 (PubMed:15231852). Catalyzes N- glucuronidation of tobacco alkaloids, tobacco-specific nitrosamines and tricyclic antidepressants (PubMed:17576790, PubMed:18238858, PubMed:20133892, PubMed:28803208). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
| Tissue Location | [Isoform 1]: Expressed in liver (PubMed:1339448, PubMed:18004212). Expressed in kidney, colon and small intestine (PubMed:18004212). Not expressed in esophagus (PubMed:18004212). Not expressed in skin (PubMed:1339448). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Kaku,T.,(2004)Biochem.Pharmacol.67(11),2093-2102ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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