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Ghitm antibody - middle region

Rabbit Polyclonal Antibody

     
  • 1 - Ghitm antibody - middle region AI12738

    WB Suggested Anti-Ghitm Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: Mouse Liver
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q91VC9
Other Accession NM_078478, NP_510963
Reactivity Human, Mouse, Rat, Rabbit, Pig, Goat, Dog, Guinea Pig, Horse, Bovine
Predicted Human, Mouse, Rat, Pig, Dog, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 37275 Da
Additional Information
Gene ID 66092
Alias Symbol 1010001P14Rik, C77840, PTD010, MICS1
Other Names Growth hormone-inducible transmembrane protein, Mitochondrial morphology and cristae structure 1, MICS1, Ghitm, Mics1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Ghitm antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGhitm antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ghitm
Synonyms Mics1
Function Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:35715207). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (PubMed:35715207). Required for the mitochondrial tubular network and cristae organization (PubMed:35715207). Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (By similarity).
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9H3K2}; Multi-pass membrane protein
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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