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Lpcat2 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8BYI6 |
| Other Accession | NM_173014, NP_766602 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Mouse, Rat, Rabbit, Pig, Chicken, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60254 Da |
| Gene ID | 270084 |
|---|---|
| Alias Symbol | A330042H22, Aytl1, LPCAT2, lpafat1, Aytl1a |
| Other Names | Lysophosphatidylcholine acyltransferase 2, LPC acyltransferase 2, LPCAT-2, LysoPC acyltransferase 2, 2.3.1.23, 1-acylglycerol-3-phosphate O-acyltransferase 11, 1-AGP acyltransferase 11, 1-AGPAT 11, 2.3.1.51, 1-acylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, 2.3.1.67, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase, Lyso-PAF acetyltransferase, LysoPAFAT, Acyltransferase-like 1, Lpcat2, Aytl1, Aytl1a, Lpcat2a |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Lpcat2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Lpcat2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Lpcat2 |
|---|---|
| Synonyms | Aytl1, Aytl1a, Lpcat2a |
| Function | Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:18156367, PubMed:18285344). Activity is calcium-dependent (PubMed:17182612). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3- phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero- 3-phosphocholine or PC) (PubMed:17182612, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O- alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl- sn-glycero-3-phosphocholine (PAF) (PubMed:17182612, PubMed:18285344). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (PubMed:17182612). Under resting conditions, acyltransferase activity is preferred (PubMed:17182612). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (PubMed:17182612). Involved in the regulation of lipid droplet number and size (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Golgi apparatus membrane; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Cell membrane; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Lipid droplet {ECO:0000250|UniProtKB:Q7L5N7} |
| Tissue Location | Highest expression is found in resident macrophages and casein-induced neutrophils followed by skin, colon, spleen and thioglycollate-induced macrophages. Detected in erythroleukemic cells but not in reticulocytes. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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