癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FBXO42 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q6P3S6 |
| Other Accession | NM_018994, NP_061867 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Mouse, Rat, Chicken, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77839 Da |
| Gene ID | 54455 |
|---|---|
| Alias Symbol | Fbx42, KIAA1332, JFK |
| Other Names | F-box only protein 42, Just one F-box and Kelch domain-containing protein, FBXO42, FBX42, JFK, KIAA1332 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FBXO42 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | FBXO42 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FBXO42 |
|---|---|
| Synonyms | FBX42, JFK, KIAA1332 |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for bipolar spindle formation during mitosis (PubMed:33539788). Recognizes p53/TP53 phosphorylated by CSN-associated kinase, promoting its polyubiquitination and proteasomal degradation (PubMed:19509332, PubMed:21127074, PubMed:39134694). Positively regulates the Notch signaling pathway through 'Lys-63'-linked polyubiquitination of the transcriptional effector RBPJ, stabilizing its chromatin association and potentiating transcriptional activation of Notch target genes (PubMed:36129980). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of components of the PP4 phosphatase complex, including PP4C, PP4R2, PP4R3A and PP4R3B, thereby restraining PP4 phosphatase activity and ensuring proper DNA damage response signaling (PubMed:41484364). Collaborates with CCDC6 to promote polyubiquitination and proteasomal degradation of the catalytic subunit PP2AC (PubMed:41986709). Recognizes ACAA2, promoting its ubiquitination and proteasomal degradation in hepatocytes, thereby attenuating fatty acid beta-oxidation; this activity is negatively regulated by CAND1, which prevents assembly of the SCF(FBXO42)-ACAA2 degradation complex (By similarity). |
| Cellular Location | Nucleus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Gregory,S.G.,(2006)Nature441(7091),315-321ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
