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DHDDS antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q86SQ9 |
| Other Accession | NM_024887, NP_079163 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Zebrafish, Pig, Chicken, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38657 Da |
| Gene ID | 79947 |
|---|---|
| Alias Symbol | CIT, CPT, DS, FLJ13102, HDS, RP59 |
| Other Names | Dehydrodolichyl diphosphate syntase complex subunit DHDDS, 2.5.1.87, Cis-isoprenyltransferase, CIT, Cis-IPTase, Epididymis tissue protein Li 189m, DHDDS, HDS |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-DHDDS antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | DHDDS antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DHDDS {ECO:0000303|PubMed:21295283, ECO:0000312|HGNC:HGNC:20603} |
|---|---|
| Function | With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Note=colocalizes with calnexin |
| Tissue Location | Ubiquitous (PubMed:21295282). Expressed at high levels in testis and kidney (PubMed:20736409). Expressed in epididymis (at protein level) (PubMed:20736409). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Endo S.,et al.Biochim. Biophys. Acta 1625:291-295(2003).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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