癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Nlgn3 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q62889 |
| Other Accession | NM_134336, NP_599163 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 93888 Da |
| Gene ID | 171297 |
|---|---|
| Other Names | Neuroligin-3, Gliotactin homolog, Nlgn3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Nlgn3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Nlgn3 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Nlgn3 |
|---|---|
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Synapse. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BYM5}. Note=Detected at both glutamatergic and GABAergic synapses. Localizes to dendritic membrane (By similarity) {ECO:0000250|UniProtKB:Q8BYM5, ECO:0000269|PubMed:17897391} |
| Tissue Location | Detected in brain and on hippocampus neurons, especially at excitatory synapses. Detected in retina (at protein level). Expressed in brain, spinal cord and dorsal root ganglion |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Ichtchenko K.,et al.J. Biol. Chem. 271:2676-2682(1996).
Gilbert M.,et al.Glia 34:151-164(2001).
Comoletti D.,et al.J. Neurosci. 24:4889-4893(2004).
Varoqueaux F.,et al.Neuron 51:741-754(2006).
Budreck E.C.,et al.Eur. J. Neurosci. 26:1738-1748(2007).
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