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JPH3 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8WXH2 |
| Other Accession | NM_020655, NP_065706 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Chicken, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 81469 Da |
| Gene ID | 57338 |
|---|---|
| Alias Symbol | CAGL237, FLJ44707, HDL2, JP-3, JP3, TNRC22 |
| Other Names | Junctophilin-3, JP-3, Junctophilin type 3, Trinucleotide repeat-containing gene 22 protein, JPH3, JP3, TNRC22 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-JPH3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | JPH3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | JPH3 |
|---|---|
| Synonyms | JP3, TNRC22 |
| Function | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. |
| Cellular Location | Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). |
| Tissue Location | Specifically expressed in brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Nishi M.,et al.Biochem. Biophys. Res. Commun. 273:920-927(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Holmes S.E.,et al.Nat. Genet. 29:377-378(2001).
Stevanin G.,et al.Neurology 58:965-967(2002).
Walker R.H.,et al.Neurology 61:1002-1004(2003).
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