癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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CACHD1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q5VU97 |
| Other Accession | NM_020925, NP_065976 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Rat, Rabbit, Pig, Chicken, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 142290 Da |
| Gene ID | 57685 |
|---|---|
| Alias Symbol | KIAA1573, RP4-655E10.1 |
| Other Names | VWFA and cache domain-containing protein 1, Cache domain-containing protein 1, CACHD1, KIAA1573, VWCD1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CACHD1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CACHD1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CACHD1 (HGNC:29314) |
|---|---|
| Function | Is a regulator of voltage-dependent calcium channels, modulating the activity of T-type calcium channels; it probably forms complexes with Cav3.1 at the cell surface and increases channel open probability (PubMed:30181139). Is also involved in the regulation of Wnt signaling, acting within a ternary complex as scaffold component that bridges FZD5 and LRP6 (By similarity). Plays a role in the regulation of neural progenitor cells proliferation and differentiation (PubMed:38158856). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in the hippocampus, thalamus, and cerebellum (PubMed:30181139). Is most abundant in dentate gyrus granule cells and pyramidal cells of the hippocampus cornu ammonis, cortical regions, and thalamus (at protein level) (PubMed:30181139) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Gregory S.G.,et al.Nature 441:315-321(2006).
Nagase T.,et al.DNA Res. 7:273-281(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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