癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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UNC84A antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | O94901 |
| Other Accession | NM_025154, NP_079430 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 87110 Da |
| Gene ID | 23353 |
|---|---|
| Alias Symbol | FLJ12407, KIAA0810, MGC176649, SUN1, UNC84A |
| Other Names | SUN domain-containing protein 1, Protein unc-84 homolog A, Sad1/unc-84 protein-like 1, SUN1, KIAA0810, UNC84A |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-UNC84A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | UNC84A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SUN1 (HGNC:18587) |
|---|---|
| Synonyms | KIAA0810, UNC84A |
| Function | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non- homologous end joining repair to facilitate the repair of DNA cross- links (PubMed:24375709). |
| Cellular Location | Nucleus inner membrane; Single-pass type II membrane protein. Note=At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles {ECO:0000250|UniProtKB:Q9D666} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Nagase T.,et al.DNA Res. 5:277-286(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hillier L.W.,et al.Nature 424:157-164(2003).
Malone C.J.,et al.Development 126:3171-3181(1999).
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