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UNC93B1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9H1C4 |
| Other Accession | NM_030930, NP_112192 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Guinea Pig, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 66631 Da |
| Gene ID | 81622 |
|---|---|
| Alias Symbol | MGC126617, UNC93, UNC93B, IIAE1, Unc-93B1 |
| Other Names | Protein unc-93 homolog B1, Unc-93B1, hUNC93B1, UNC93B1, UNC93, UNC93B |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-UNC93B1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | UNC93B1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UNC93B1 (HGNC:13481) |
|---|---|
| Synonyms | UNC93, UNC93B |
| Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome Lysosome. Cytoplasmic vesicle, phagosome Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity) Colocalizes with LAMP5 in large endosomal intracellular vesicles {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595} |
| Tissue Location | Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Kashuba V.I.,et al.Gene 283:209-217(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
Kollewe A.,et al.Thesis (2001), University of Hannover, Germany.
Olsen J.V.,et al.Cell 127:635-648(2006).
Casrouge A.,et al.Science 314:308-312(2006).
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