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Tmem147 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q2TA63 |
| Other Accession | NM_001038494, NP_001033583 |
| Reactivity | Human, Mouse, Rat, Rabbit, Goat, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rabbit, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25291 Da |
| Gene ID | 292792 |
|---|---|
| Alias Symbol | MGC125231, RGD1304706 |
| Other Names | Transmembrane protein 147, Tmem147 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Tmem147 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Tmem147 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Tmem147 {ECO:0000312|RGD:1304706} |
|---|---|
| Function | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BVK8}; Multi-pass membrane protein. Nucleus membrane {ECO:0000250|UniProtKB:Q9BVK8}; Multi- pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:I6VSD2}; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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