癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Prkcdbp Antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q91VJ2 |
| Other Accession | NM_028444, NP_082720 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27853 Da |
| Gene ID | 109042 |
|---|---|
| Alias Symbol | 3110015B12Rik, 6330514M23Rik, MGC6598, SRBC |
| Other Names | Protein kinase C delta-binding protein, Cavin-3, Serum deprivation response factor-related gene product that binds to C-kinase, Prkcdbp, Srbc |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Prkcdbp antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Prkcdbp Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Cavin3 |
|---|---|
| Synonyms | Prkcdbp, Srbc |
| Function | Regulates the traffic and/or budding of caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells (PubMed:23652019, PubMed:28285351). Regulates the equilibrium between cell surface- associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface (PubMed:25588833). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (PubMed:23079727). |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol. Membrane, caveola Note=Localizes in the caveolae in a caveolin-dependent manner |
| Tissue Location | Lung, heart, skeletal muscle, liver, brain, vascular and urinary bladder smooth muscle (at protein level). Strongly expressed in uterus, ovary, mammary and epithelial cells. Also expressed in spleen, intestine, kidney and testis |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Carninci P.,et al.Science 309:1559-1563(2005).
Izumi Y.,et al.J. Biol. Chem. 272:7381-7389(1997).
Villen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Schneider K.,et al.EMBO Rep. 13:1138-1144(2012).
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