癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C9orf75 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q4KMQ1 |
| Other Accession | NM_173691, NP_775962 |
| Reactivity | Human, Mouse, Rat, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75556 Da |
| Gene ID | 286262 |
|---|---|
| Alias Symbol | FLJ90254, MGC131933, RP11-350O14.7, DFNB79, C9orf75 |
| Other Names | Taperin, TPRN, C9orf75 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-C9orf75 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | C9orf75 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TPRN |
|---|---|
| Synonyms | C9orf75 |
| Function | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). |
| Cellular Location | Cell projection, stereocilium {ECO:0000250|UniProtKB:A2AI08}. Cell projection, microvillus {ECO:0000250|UniProtKB:A2AI08}. Nucleus, nucleoplasm. Cytoplasm Note=Localized prominently at the basal taper region of hair cell stereocilia (By similarity). Forms organized ring-like structures with diameters ranging from 150 to 200 nm in the stereocilium taper region (By similarity). Detected in microvilli of inner hair cell supporting cells (By similarity). Predominantly nuclear in non-stereocilium cells but can shuttle between the nucleus and the cytoplasm (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405} |
| Tissue Location | Expression is detected in fetal cochlea. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
