癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Pde2a antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q01062 |
| Other Accession | NM_001143847, NP_001137319 |
| Reactivity | Human, Mouse, Rat, Dog, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 104664 Da |
| Gene ID | 81743 |
|---|---|
| Alias Symbol | Pde2, Pde2a2, Pde2a |
| Other Names | cGMP-dependent 3', 5'-cyclic phosphodiesterase, 3.1.4.17, Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE, Pde2a |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Pde2a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Pde2a antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Pde2a {ECO:0000312|RGD:620965} |
|---|---|
| Function | cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity). |
| Cellular Location | [Isoform PDE2A3]: Cell membrane {ECO:0000250|UniProtKB:O00408}; Peripheral membrane protein [Isoform PDE2A2]: Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane |
| Tissue Location | Expressed in brain and liver. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Yang Q.,et al.Biochem. Biophys. Res. Commun. 205:1850-1858(1994).
Repaske D.R.,et al.J. Biol. Chem. 267:18683-18688(1992).
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