癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RAB39 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8BHD0 |
| Other Accession | NM_017516, NP_059986 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Guinea Pig, Horse, Bovine |
| Predicted | Mouse, Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24978 Da |
| Gene ID | 270160 |
|---|---|
| Alias Symbol | RAB39 |
| Other Names | Ras-related protein Rab-39A, Rab-39, Rab39a, Rab39 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RAB39 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RAB39 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Rab39a {ECO:0000312|MGI:MGI:2442855} |
|---|---|
| Synonyms | Rab39 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB39A regulates autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex onto lysosomes; this process involves lysosomal RAB39A and autophagosomal RAB2A recruitment of HOPS subcomplexes VPS41-VPS16-VPS18-VPS33A and VPS39-VPS11, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (By similarity). Also negatively regulates lipopolysaccharide (LPS)-induced autophagosome formation in macrophages, possibly by implicating PI3K (By similarity). Promotes the delivery of MHC-I molecules from the ER to phagosomes and the generation of peptide-loaded MHC-I complexes in phagosomes, thus enhancing antigen cross-presentation by dendritic cells (PubMed:31821587). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes (By similarity). May be involved in multiple neurite formation (PubMed:23624502). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Late endosome membrane. Lysosome membrane {ECO:0000250|UniProtKB:Q14964}. Autolysosome membrane {ECO:0000250|UniProtKB:Q14964}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. Majorly localized on lysosomes under basal conditions (By similarity). Majorly localized on autophagosomes/autolysosomes under autophagy-induced conditions (By similarity). Colocalized with VPS39 and VPS41 on lysosomes or autolysosomes (By similarity). Colocalized with STX17 on autolysosomes in autophagy-induced conditions (By similarity). Localized (GTP-bound) to phagosomes in dendritic cells; shuttles vesicles from the ER-Golgi to the phagosome (PubMed:31821587). {ECO:0000250|UniProtKB:Q14964, ECO:0000269|PubMed:31821587} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Carninci P.,et al.Science 309:1559-1563(2005).
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