癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RAB22A antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | P35285 |
| Other Accession | NM_020673, NP_065724 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21802 Da |
| Gene ID | 19334 |
|---|---|
| Alias Symbol | MGC16770 |
| Other Names | Ras-related protein Rab-22A, Rab-22, Rab-14, Rab22a, Rab22 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RAB22A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RAB22A antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Rab22a {ECO:0000312|MGI:MGI:105072} |
|---|---|
| Synonyms | Rab22 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:19759177, PubMed:27718357). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB22A plays a role in endocytosis and intracellular protein transport (PubMed:19759177, PubMed:27718357). Mediates trafficking of transferrin/TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Has low GTPase activity (By similarity). |
| Cellular Location | Endosome membrane; Lipid-anchor. Cell membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor. Early endosome Late endosome {ECO:0000250|UniProtKB:P51154}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9UL26}. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9UL26}. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250|UniProtKB:Q9UL26} |
| Tissue Location | Detected in brain and heart, and at lower levels in lung and spleen. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Kussmann S.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Chavrier P.,et al.Gene 112:261-264(1992).
Olkkonen V.M.,et al.J. Cell Sci. 106:1249-1261(1993).
Zhu H.,et al.Mol. Biol. Cell 20:4720-4729(2009).
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