癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Ppp3cb antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P48453 |
| Other Accession | NM_008914, NP_032940 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59173 Da |
| Gene ID | 19056 |
|---|---|
| Alias Symbol | 1110063J16Rik, Calnb, CnAbeta, Cnab |
| Other Names | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, 3.1.3.16, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit beta isoform, Ppp3cb, Calnb |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ppp3cb antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ppp3cb antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ppp3cb |
|---|---|
| Synonyms | Calnb |
| Function | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (By similarity). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (By similarity). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (PubMed:26029823). May play a role in skeletal muscle fiber type specification (PubMed:12773574). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P16298}. |
| Tissue Location | Expressed in kidney, in the thick ascending limb epithelium and in the collecting duct, but not in the distal convoluted tubule (at protein level) (PubMed:15509543, PubMed:25967121). Expressed in the brain and the bicep, tricep, soleus and gastrocnemius muscles (at protein level) (PubMed:12773574). Expressed in the salivary gland (at protein level) (PubMed:21435446). Expressed in hippocampal neuron nuclei and adjacent white matter tracts in the CA1 region of the hippocampus (at protein level) (PubMed:10200317) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Giri P.R.,et al.Biochem. Biophys. Res. Commun. 181:252-258(1991).
Gaestel M.,et al.J. Biol. Chem. 267:21607-21611(1992).
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