癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Trim3 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9R1R2 |
| Other Accession | NM_018880, NP_061368 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 80774 Da |
| Gene ID | 55992 |
|---|---|
| Alias Symbol | BERP1, HAC1, Rnf22 |
| Other Names | Tripartite motif-containing protein 3, RING finger protein 22, RING finger protein HAC1, Trim3, Hac1, Rnf22 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Trim3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Trim3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Trim3 |
|---|---|
| Synonyms | Hac1, Rnf22 |
| Function | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:24086586, PubMed:26527743). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation (By similarity). Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (PubMed:26527743). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (PubMed:24086586). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquitinates CDKN1A. Positively regulates TLR3- mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:26527743). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O75382}. Early endosome {ECO:0000250|UniProtKB:O75382}. Golgi apparatus, trans-Golgi network. Cell projection, dendrite. Note=Mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with dsRNA. {ECO:0000250|UniProtKB:O75382} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Yanai K.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Reymond A.,et al.EMBO J. 20:2140-2151(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).
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