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JARID2 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q92833 |
| Other Accession | NM_017566, NP_004964 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Rabbit, Pig, Guinea Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 138734 Da |
| Gene ID | 3720 |
|---|---|
| Alias Symbol | JMJ |
| Other Names | Protein Jumonji, Jumonji/ARID domain-containing protein 2, JARID2, JMJ |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-JARID2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | JARID2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JARID2 |
|---|---|
| Synonyms | JMJ |
| Function | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137}. Note=Colocalizes with the PRC2 complex on chromatin. |
| Tissue Location | During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Berge-Lefranc J.-L.,et al.Hum. Mol. Genet. 5:1637-1641(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Choudhary C.,et al.Science 325:834-840(2009).
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