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GNAI3 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P08754 |
| Other Accession | NM_006496, NP_006487 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Goat, Dog, Guinea Pig, Horse, Bovine, Sheep |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40532 Da |
| Gene ID | 2773 |
|---|---|
| Alias Symbol | 87U6, FLJ26559 |
| Other Names | Guanine nucleotide-binding protein G(k) subunit alpha, G(i) alpha-3, GNAI3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-GNAI3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GNAI3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNAI3 |
|---|---|
| Function | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). |
| Cellular Location | Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes in the centrosomes of interphase and mitotic cells Detected at the cleavage furrow and/or the midbody |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Didsbury J.R.,et al.FEBS Lett. 219:259-263(1987).
Beals C.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:7886-7890(1987).
Itoh H.,et al.J. Biol. Chem. 263:6656-6664(1988).
Codina J.,et al.J. Biol. Chem. 263:6746-6750(1988).
Kim S.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4153-4157(1988).
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