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Pcsk1n Antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9QXU9 |
| Other Accession | NM_019279, NP_062152 |
| Reactivity | Human, Mouse, Rat, Dog, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Dog, Guinea Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27414 Da |
| Gene ID | 246333 |
|---|---|
| Alias Symbol | Saas |
| Other Names | ProSAAS, Proprotein convertase subtilisin/kexin type 1 inhibitor, Proprotein convertase 1 inhibitor, pro-SAAS, KEP, Big SAAS, b-SAAS, Little SAAS, l-SAAS, Big PEN-LEN, b-PEN-LEN, SAAS CT(1-49), PEN, PEN-20, Little LEN, l-LEN, Big LEN, b-LEN, SAAS CT(25-40), Pcsk1n |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Pcsk1n antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Pcsk1n Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Pcsk1n |
|---|---|
| Function | May act as a protein chaperone that prevents the aggregation of client proteins and plays a role in neuroprotection. Blocks the trans-synaptic spread of SNCA/alpha-synuclein in the brain. May form spheres that encapsulate client proteins. May prevent aggregation of amyloid beta and SNCA/alpha-synuclein. Cannot disaggregate preformed fibrils. Additionally, may regulate the neuroendocrine secretory pathway by acting as a specific endogenous inhibitor of PCSK1 (PubMed:10632593, PubMed:10816562). ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, reduce the activity of the 87 kDa form of PCSK1, but not the autocatalytically derived 66 kDa form, in the endoplasmic reticulum and Golgi (PubMed:10632593, PubMed:10816562). May control the intracellular timing of PCSK1 rather than its total level of activity and slows down convertase-mediated processing of proopiomelanocortin and proenkephalin (By similarity). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q9QXV0}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9QXV0} Note=Proteotoxic stress stimulates its intracellular retention {ECO:0000250|UniProtKB:Q9QXV0} |
| Tissue Location | Expressed in adult brain (all major structural regions), adrenal gland (medulla) and spinal cord (dorsal and ventral horn). Expressed in pancreatic islands. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Fricker L.,et al.J. Neurosci. 20:639-648(2000).
Donadel G.,et al.Neuroendocrinology 67:190-196(1998).
Qian Y.,et al.J. Biol. Chem. 275:23596-23601(2000).
Mzhavia N.,et al.Biochem. J. 361:67-76(2002).
Morgan D.J.,et al.J. Neurochem. 93:1454-1462(2005).
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