癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Hcrt Antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O55232 |
| Other Accession | NM_013179, NP_037311 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine, Sheep |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13645 Da |
| Gene ID | 25723 |
|---|---|
| Alias Symbol | orexin-A |
| Other Names | Orexin, Hypocretin, Hcrt, Orexin-A, Hypocretin-1, Hcrt1, Orexin-B, Hypocretin-2, Hcrt2, Hcrt, Ox, Ppox |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Hcrt antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Hcrt Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Hcrt {ECO:0000312|RGD:2786} |
|---|---|
| Synonyms | Ox, Ppox |
| Function | Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions (PubMed:11283317, PubMed:11340621, PubMed:9491897). A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested (PubMed:9491897). A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function (PubMed:11340621, PubMed:9879756). |
| Cellular Location | Rough endoplasmic reticulum. Cytoplasmic vesicle. Synapse Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses |
| Tissue Location | Mainly expressed in the brain, with expression in neurons in the dorsal lateral hypothalamic area (at protein level) (PubMed:9419374). Produced by a small group of neurons restricted to the lateral and posterior hypothalamus and perifornical areas (PubMed:9491897). Positive neurons project widely throughout the entire neuroaxis (PubMed:9491897). Particularly abundant projections in the cerebral cortex, olfactory bulb, hippocampus, amygdala, septum, diagonal band of Broca, bed nucleus of the stria terminalis, thalamus, anterior and posterior hypothalamus, midbrain, brainstem, and spinal cord (PubMed:9491897). Also expressed in the enteric nervous system and pancreas (PubMed:9491897). In small amount, also detected in the testis (PubMed:9491897). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Sakurai T.,et al.Cell 92:573-585(1998).
de Lecea L.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:322-327(1998).
Hungs M.,et al.Bioessays 23:397-408(2001).
Willie J.T.,et al.Annu. Rev. Neurosci. 24:429-458(2001).
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