癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OPRL1 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P79292 |
| Other Accession | NM_182647, NP_872588 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Goat, Dog, Guinea Pig, Horse, Bovine, Sheep |
| Predicted | Human, Mouse, Rat, Zebrafish, Chicken, Dog, Guinea Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40610 Da |
| Gene ID | 397364 |
|---|---|
| Alias Symbol | KOR-3, MGC34578, NOCIR, OOR, ORL1 |
| Other Names | Nociceptin receptor, K3 opiate receptor, Kappa-type 3 opioid receptor, KOR-3, ORGC, Orphanin FQ receptor, OPRL1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-OPRL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | OPRL1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OPRL1 |
|---|---|
| Function | G protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane (By similarity). |
| Tissue Location | Detected in brain cortex, stomach, ileum, jejunum and colon. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Osinski M.A.,et al.Eur. J. Pharmacol. 365:281-289(1999).
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