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PITPNM1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O35954 |
| Other Accession | NM_001130848, NP_001124320 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Pig, Chicken, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 134940 Da |
| Gene ID | 18739 |
|---|---|
| Alias Symbol | DRES9, FLJ44997, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9 |
| Other Names | Membrane-associated phosphatidylinositol transfer protein 1, Drosophila retinal degeneration B homolog 1, RdgB1, Mpt-1, Phosphatidylinositol transfer protein, membrane-associated 1, PITPnm 1, Pyk2 N-terminal domain-interacting receptor 2, NIR-2, Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PITPNM1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PITPNM1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Pitpnm1 |
|---|---|
| Synonyms | Dres9, Mpt1, Nir2, Pitpnm |
| Function | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (By similarity). Binds PI (PubMed:10400687). Also binds phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (By similarity). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (By similarity). Necessary for normal completion of cytokinesis (By similarity). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (By similarity). Required for protein export from the endoplasmic reticulum and the Golgi (By similarity). Binds calcium ions (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O00562}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:O00562}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00562}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00562}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00562}. Lipid droplet {ECO:0000250|UniProtKB:O00562}. Cleavage furrow {ECO:0000250|UniProtKB:O00562}. Midbody {ECO:0000250|UniProtKB:O00562} Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis. {ECO:0000250|UniProtKB:O00562} |
| Tissue Location | Detected at high levels in brain, and at lower levels in lung, kidney, spleen and liver (at protein level) Ubiquitous. Highly expressed in embryonic retina and the central nervous system. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Aikawa Y.,et al.Biochem. Biophys. Res. Commun. 236:559-564(1997).
Rubboli F.,et al.Genes Funct. 1:205-213(1997).
Aikawa Y.,et al.J. Biol. Chem. 274:20569-20577(1999).
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