癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Rab5a antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9CQD1 |
| Other Accession | NM_025887, NP_080163 |
| Reactivity | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Bovine, Sheep |
| Predicted | Human, Mouse, Rat, Pig, Chicken, Dog, Guinea Pig, Bovine, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 23599 Da |
| Gene ID | 271457 |
|---|---|
| Alias Symbol | 2410015H04Rik, AI663973, AU021172 |
| Other Names | Ras-related protein Rab-5A, Rab5a, nnyRab5a |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Rab5a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Rab5a antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Rab5a {ECO:0000312|MGI:MGI:105926} |
|---|---|
| Synonyms | nnyRab5a |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (PubMed:18425118). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}; Cytoplasmic side {ECO:0000250|UniProtKB:P18066}. Early endosome membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}. Melanosome. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P20339}. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane {ECO:0000250|UniProtKB:P20339}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P20339}. Cytoplasmic vesicle, phagosome membrane. Endosome membrane {ECO:0000250|UniProtKB:P20339}. Note=Enriched in stage I melanosomes Alternates between membrane-bound and cytosolic forms {ECO:0000250|UniProtKB:P20339} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Kuroda T.S.,et al.J. Biol. Chem. 277:9212-9218(2002).
Itoh T.,et al.Genes Cells 11:1023-1037(2006).
Carninci P.,et al.Science 309:1559-1563(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Lubec G.,et al.Submitted (APR-2007) to UniProtKB.
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