DDO antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application ![]()
| WB |
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Primary Accession | Q99489 |
Other Accession | NM_003649, NP_003640 |
Reactivity | Human, Rabbit, Pig, Dog, Horse, Bovine |
Predicted | Human, Rabbit, Pig, Chicken, Dog, Horse, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 37535 Da |
Gene ID | 8528 |
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Alias Symbol | DASOX, DDO-1, DDO-2, FLJ45203 |
Other Names | D-aspartate oxidase, DASOX, DDO, 1.4.3.1, DDO |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-DDO antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | DDO antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DDO |
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Function | Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:1991137, PubMed:20603179, PubMed:23391306, PubMed:25747990, PubMed:28393897, PubMed:28560262, PubMed:28629864, PubMed:29292239, PubMed:31914658, PubMed:32553892, PubMed:9163533). Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (PubMed:28560262). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (By similarity). |
Cellular Location | Peroxisome matrix. Cytoplasm, cytosol. Note=Active in the peroxisomal matrix [Isoform 3]: Peroxisome matrix |
Tissue Location | Expressed in epithelial cells of the proximal nephron tubules in the renal cortex (at protein level) (PubMed:12209855, PubMed:1991137). In the brain, expressed in the frontal, temporal, and occipital lobes of the cortex, hippocampus, striatum, diencephalon, brainstem, cerebellum, spinal cord, plexus choroiderus and ependyma (at protein level) (PubMed:12209855, PubMed:28560262). Expression is increased in the prefrontal cortex of schizophrenic patients (PubMed:25689573). Levels are normal in the superior frontal gyrus of patients with Alzheimer's disease (PubMed:30822420). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Setoyama C.,et al.J. Biochem. 121:798-803(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Birkett C.,et al.Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.

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