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>   首页   >   产品   >   一抗   >   代谢   >   DDO antibody - N-terminal region   

DDO antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • 1 - DDO antibody - N-terminal region AI14650

    WB Suggested Anti-DDO Antibody Titration: 1.0 μg/ml
    Positive Control: HepG2 Whole Cell
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q99489
Other Accession NM_003649, NP_003640
Reactivity Human, Rabbit, Pig, Dog, Horse, Bovine
Predicted Human, Rabbit, Pig, Chicken, Dog, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 37535 Da
Additional Information
Gene ID 8528
Alias Symbol DASOX, DDO-1, DDO-2, FLJ45203
Other Names D-aspartate oxidase, DASOX, DDO, 1.4.3.1, DDO
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-DDO antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsDDO antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DDO
Function Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:1991137, PubMed:20603179, PubMed:23391306, PubMed:25747990, PubMed:28393897, PubMed:28560262, PubMed:28629864, PubMed:29292239, PubMed:31914658, PubMed:32553892, PubMed:9163533). Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (PubMed:28560262). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (By similarity).
Cellular Location Peroxisome matrix. Cytoplasm, cytosol. Note=Active in the peroxisomal matrix [Isoform 3]: Peroxisome matrix
Tissue Location Expressed in epithelial cells of the proximal nephron tubules in the renal cortex (at protein level) (PubMed:12209855, PubMed:1991137). In the brain, expressed in the frontal, temporal, and occipital lobes of the cortex, hippocampus, striatum, diencephalon, brainstem, cerebellum, spinal cord, plexus choroiderus and ependyma (at protein level) (PubMed:12209855, PubMed:28560262). Expression is increased in the prefrontal cortex of schizophrenic patients (PubMed:25689573). Levels are normal in the superior frontal gyrus of patients with Alzheimer's disease (PubMed:30822420).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

Setoyama C.,et al.J. Biochem. 121:798-803(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Birkett C.,et al.Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.

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