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Mapre1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q61166 |
| Other Accession | NM_007896, NP_031922 |
| Reactivity | Human, Mouse, Rat, Rabbit, Goat, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Mouse, Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30016 Da |
| Gene ID | 13589 |
|---|---|
| Alias Symbol | 5530600P05Rik, AI462499, AI504412, AW260097, BIM1p, D2Ertd459e, Eb1 |
| Other Names | Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1, Mapre1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Mapre1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Mapre1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Mapre1 |
|---|---|
| Function | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (PubMed:15311282). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with DSP, thereby facilitating gap junction intracellular communication (By similarity). May play a role in cell migration (PubMed:15311282). |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q15691} Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q15691} Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q15691} Cell membrane {ECO:0000250|UniProtKB:Q15691}. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:21357749). In addition to localizing to microtubule plus-ends, also exhibits some localization along the length of the microtubules (By similarity). Also enriched at the centrosome (By similarity) {ECO:0000250|UniProtKB:Q15691, ECO:0000269|PubMed:21357749} |
| Tissue Location | Expressed within the midpiece of sperm tail (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Sparks A.B.,et al.Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (FEB-2008) to UniProtKB.
Wen Y.,et al.Nat. Cell Biol. 6:820-830(2004).
Wu X.,et al.Cell 135:137-148(2008).
Fong K.W.,et al.Mol. Biol. Cell 20:3660-3670(2009).
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