EIF3F antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application ![]()
| WB |
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Primary Accession | O00303 |
Other Accession | NM_003754, NP_003745 |
Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Horse, Bovine |
Predicted | Human, Mouse, Rat, Rabbit, Chicken, Dog, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 37564 Da |
Gene ID | 8665 |
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Alias Symbol | EIF3S5, eIF3-p47 |
Other Names | Eukaryotic translation initiation factor 3 subunit F {ECO:0000255|HAMAP-Rule:MF_03005}, eIF3f {ECO:0000255|HAMAP-Rule:MF_03005}, Deubiquitinating enzyme eIF3f, 3.4.19.12, Eukaryotic translation initiation factor 3 subunit 5 {ECO:0000255|HAMAP-Rule:MF_03005}, eIF-3-epsilon {ECO:0000255|HAMAP-Rule:MF_03005}, eIF3 p47 {ECO:0000255|HAMAP-Rule:MF_03005}, EIF3F {ECO:0000255|HAMAP-Rule:MF_03005} |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-EIF3F antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | EIF3F antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EIF3F {ECO:0000255|HAMAP-Rule:MF_03005} |
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Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). |
Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.

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