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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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ADAT3 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q96EY9 |
| Other Accession | NM_138422, NP_612431 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39844 Da |
| Gene ID | 113179 |
|---|---|
| Alias Symbol | FWP005, MST121, MSTP121, S863-5, TAD3 |
| Other Names | Probable inactive tRNA-specific adenosine deaminase-like protein 3, tRNA-specific adenosine-34 deaminase subunit ADAT3, ADAT3, TAD3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ADAT3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ADAT3 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADAT3 |
|---|---|
| Synonyms | TAD3 |
| Function | Non-catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the ADAT2 catalytic subunit and the ADAT3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A. Required for binding of the ADAT2-ADAT3 complex to tRNA through its N- terminus, which rotates with respect to the catalytic domain of the complex, formed by ADAT2 and the ADAT3 C-terminal domain, to position the tRNA anticodon stem-loop correctly in the ADAT2 active site. The ADAT2-ADAT3 complex is required for radial migration of projection neurons in the developing brain cortex, and the catalytic activity of the complex is necessary for this function. |
| Cellular Location | Nucleus. Cytoplasm. Note=The ADAT2-ADAT3 complex shows a diffuse expression pattern in both the cytoplasm and the nucleus {ECO:0000250|UniProtKB:Q6PAT0} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Sjoeblom T.,et al.Science 314:268-274(2006).
Alazami A.M.,et al.J. Med. Genet. 50:425-430(2013).
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