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GPR52 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9Y2T5 |
| Other Accession | NM_005684, NP_005675 |
| Reactivity | Human, Mouse, Rat, Pig, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Guinea Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41354 Da |
| Gene ID | 9293 |
|---|---|
| Alias Symbol | MGC111751 |
| Other Names | Probable G-protein coupled receptor 52, GPR52 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-GPR52 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GPR52 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508} |
|---|---|
| Function | Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in brain, especially in striatum. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Sawzdargo M.,et al.Brain Res. Mol. Brain Res. 64:193-198(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).
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