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SNRPE antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P62304 |
| Other Accession | NM_003094, NP_003085 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Dog, Guinea Pig, Bovine |
| Predicted | Mouse, Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 10804 Da |
| Gene ID | 6635 |
|---|---|
| Alias Symbol | B-raf, SME, Sm-E |
| Other Names | Small nuclear ribonucleoprotein E, snRNP-E, Sm protein E, Sm-E, SmE, SNRPE |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SNRPE antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SNRPE antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNRPE |
|---|---|
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23246290, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). |
| Cellular Location | Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. |
| Tissue Location | Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
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